Journal: mSphere
Article Title: Genome Structural Diversity among 31 Bordetella pertussis Isolates from Two Recent U.S. Whooping Cough Statewide Epidemics
doi: 10.1128/mSphere.00036-16
Figure Lengend Snippet: Large-scale genome rearrangements within a subset of California (H561 and H563, blue) and Vermont (I496 and I707, red) epidemic isolates compared to vaccine strains E476 and C393 as visualized by whole-genome restriction mapping and alignment with MapSolver (A) and genome sequence alignment with progressiveMauve (B). Connecting lines indicate either conserved restriction fragments (A) or homologous sequence blocks (B). Sequence maps begin at the replication origin, and the approximate replication terminus is indicated with an arrow.
Article Snippet: Restriction map alignments between different strains were generated using MapSolver software (v.2.1.1; OpGen, Gaithersburg, MD).
Techniques: Sequencing